Systems Biology of Cell Signaling : Recurring Themes and Quantitative Models

Description: How can we understand the complexity of genes, RNAs, and proteins and the associated regulatory networks? One approach is to look for recurring types of dynamical behavior. Mathematical models prove to be useful, especially models coming from theories of biochemical reactions such as ordinary differential equation models. Clever, careful experiments test these models and their basis in specific theories. This textbook aims to provide advanced students with the tools and insights needed to carry out studies of signal transduction drawing on modeling, theory, and experimentation. Early chapters summarize the basic building blocks of signaling systems: binding/dissociation, synthesis/destruction, and activation/inactivation. Subsequent chapters introduce various basic circuit devices: amplifiers, stabilizers, pulse generators, switches, stochastic spike generators, and oscillators. All chapters consistently use approaches and concepts from chemical kinetics and nonlinear dynamics, including rate-balance analysis, phase plane analysis, nullclines, linear stability analysis, stable nodes, saddles, unstable nodes, stable and unstable spirals, and bifurcations. This textbook seeks to provide quantitatively inclined biologists and biologically inclined physicists with the tools and insights needed to apply modeling and theory to interesting biological processes. Key Features: Full-color illustration program with diagrams to help illuminate the concepts Enables the reader to apply modeling and theory to the biological processes Further Reading for each chapter

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Location: Westland, Michigan

End Time: 2024-09-12T01:35:19.000Z

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Number of Pages: 266 Pages

Language: English

Publication Name: Systems Biology of Cell Signaling : Recurring Themes and Quantitative Models

Publisher: Taylor & Francis Group

Subject: Life Sciences / Cell Biology, Life Sciences / Anatomy & Physiology (See Also Life Sciences / Human Anatomy & Physiology), Life Sciences / General

Publication Year: 2021

Item Weight: 28.4 Oz

Type: Textbook

Author: James E. Ferrell

Item Length: 11 in

Subject Area: Science

Item Width: 8.2 in

Format: Trade Paperback