Theory of Phase Transitions in Polypeptides and Proteins by Alexander V. Yakubov

Description: Theory of Phase Transitions in Polypeptides and Proteins by Alexander V. Yakubovich There are nearly 100 000 different protein sequences encoded in the human genome, each with its own specific fold. The major novelty of this work lies in combining (a) a formalism based on fundamental physical properties of the system and (b) the resulting possibility of describing the folding↔unfolding transitions quantitatively. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description There are nearly 100 000 different protein sequences encoded in the human genome, each with its own specific fold. Understanding how a newly formed polypeptide sequence finds its way to the correct fold is one of the greatest challenges in the modern structural biology. The aim of this thesis is to provide novel insights into protein folding by considering the problem from the point of view of statistical mechanics. The thesis starts by investigating the fundamental degrees of freedom in polypeptides that are responsible for the conformational transitions. This knowledge is then applied in the statistical mechanics description of helix↔coil transitions in polypeptides. Finally, the theoretical formalism is generalized to the case of proteins in an aqueous environment. The major novelty of this work lies in combining (a) a formalism based on fundamental physical properties of the system and (b) the resulting possibility of describing the folding↔unfolding transitions quantitatively. The clear physical nature of the formalism opens the way to further applications in a large variety of systems and processes. Back Cover There are nearly 100 000 different protein sequences encoded in the human genome, each with its own specific fold. Understanding how a newly formed polypeptide sequence finds its way to the correct fold is one of the greatest challenges in the modern structural biology. The aim of this thesis is to provide novel insights into protein folding by considering the problem from the point of view of statistical mechanics. The thesis starts by investigating the fundamental degrees of freedom in polypeptides that are responsible for the conformational transitions. This knowledge is then applied in the statistical mechanics description of helix↔coil transitions in polypeptides. Finally, the theoretical formalism is generalized to the case of proteins in an aqueous environment. The major novelty of this work lies in combining (a) a formalism based on fundamental physical properties of the system and (b) the resulting possibility of describing the folding↔unfolding transitions quantitatively. The clear physical nature of the formalism opens the way to further applications in a large variety of systems and processes. Table of Contents Introduction.- Theoretical Methods of Quantum Mechanics.- Degrees of Freedom in Polypeptides and Proteins.- Partition Function of a Polypeptide.- Phase Transitions in Polypeptides.- Folding of Proteins in Aqueous Environment. Feature Nominated as an outstanding contribution by the University of Frankfurt Represents a fertile encounter between physics and life-sciences Presents the first physically motivated quantitative description of the protein folding/unfolding transition Details ISBN3642269532 Author Alexander V. Yakubovich Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Series Springer Theses Year 2013 ISBN-10 3642269532 ISBN-13 9783642269530 Format Paperback Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K Place of Publication Berlin Country of Publication Germany DEWEY 572.65 Short Title THEORY OF PHASE TRANSITIONS IN Language English Media Book Pages 121 Edition 2011th Illustrations 11 Illustrations, color; 28 Illustrations, black and white; XIII, 121 p. 39 illus., 11 illus. in color. Publication Date 2013-11-27 Edition Description 2011 ed. Alternative 9783642225918 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96371119;

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